• GI 254023X: Precision ADAM10 Inhibition

  2026-08-22

  GI 254023X offers translational researchers a selective ADAM10 inhibitor for connecting sheddase activity with Notch1 signaling, Jurkat-cell phenotypes, endothelial barrier protection, and vascular integrity. This thought-leadership perspective places the compound within a disciplined evidence framework, using partial BACE inhibition findings to highlight why exposure, selectivity, and functional endpoints must be interpreted together.

• Moesin as a Biomarker of Endothelial Injury in Sepsis

  2026-08-22

  The reference study identifies circulating moesin as a biomarker associated with sepsis severity and links it mechanistically to endothelial hyperpermeability through ROCK1/MLC and NF-κB signaling. Its combination of patient samples, mouse sepsis models, and HMEC experiments provides a useful framework for distinguishing biomarker association from endothelial injury mechanisms.

• Neuromedin S (rat): Protocol and QC Guide

  2026-08-20

  Neuromedin S (rat) provides a defined peptide agonist for controlled neuromedin U receptor signaling studies in rat-relevant in vitro and ex vivo workflows. It should be handled as a research reagent, not used for diagnostic, therapeutic, clinical, or unsupported cross-species applications.

• LDH Cytotoxicity Assay Kit for Nanomaterial Safety

  2026-08-20

  Discover how the LDH Cytotoxicity Assay Kit supports rigorous cell cytotoxicity measurement in magnetite–cellulose nanocrystal research. This guide connects membrane-integrity data with surface chemistry, magnetic hyperthermia, and orthogonal death-pathway validation.

• Brefeldin A: ER Stress Workflow Guide

  2026-08-19

  Brefeldin A (BFA) provides a direct way to perturb ER-to-Golgi trafficking while monitoring ER stress, secretion, cytoskeletal remodeling, and apoptosis in the same experimental system. This guide translates that mechanism into practical workflows for cancer, protein transport, and hypothesis-generating endothelial injury studies.

• Cy5 amine (non-sulfonated): Protocol Guide

  2026-08-19

  Cy5 amine (non-sulfonated), SKU A8143, provides a primary amine for covalent attachment of a bright near-infrared cyanine dye to activated labeling partners. Its water-insoluble profile requires dissolution in DMSO or ethanol before transfer into compatible biomolecule-labeling workflows; it is not intended for direct aqueous labeling, diagnostic use, or medical applications.

• Trilaurin: Practical Formulation and QC Guide

  2026-08-18

  Trilaurin (Glycerol Tridodecanoate) is a water-insoluble, long-chain triacylglycerol used as a lipid excipient, formulation component, and biocatalytic synthesis substrate. This guide covers solvent selection, handling, formulation controls, and assay design while defining where dossier-level application information should not be treated as a validated protocol.

• Mycophenolic Acid: Metabolic Control in Immune Assays

  2026-08-18

  A translational perspective on how Mycophenolic acid, a dehydrogenase inhibitor, can sharpen whole-blood immunometabolism studies by connecting nucleotide biosynthesis with cytokine response, assay design, and decision-making beyond conventional product-page claims.

• CD47, Vav Dephosphorylation, and Phagocytosis

  2026-08-17

  Miller and colleagues identify Vav dephosphorylation as a key signaling event through which CD47 suppresses Rac-dependent macrophage phagocytosis. Time-lapse imaging and genetic pathway perturbations show that CD47 changes the mode and frequency of target internalization without preventing Syk activation or Vav recruitment, refining the mechanism of the macrophage don’t-eat-me signal.

• Dual-Action Inhibitors and p38α Dephosphorylation

  2026-08-17

  The reference preprint shows that some p38α kinase inhibitors do more than occupy the catalytic site: they shift the activation loop into a conformation that allows WIP1 to remove its activating phosphate more efficiently. This structural mechanism suggests a route to stronger and more selective control of kinase signaling, while also highlighting why inhibitor-specific evidence is essential when interpreting p38 MAPK inhibitor activity.

• Brefeldin A Workflows for ER Stress Studies

  2026-08-16

  Brefeldin A provides temporal control over ER-to-Golgi trafficking, making it useful for dissecting secretion, ER stress, and apoptosis in cancer and endothelial-cell assays. This workflow-led guide connects BFA treatment design with permeability and biomarker readouts while separating established product uses from exploratory sepsis applications.

• LNP Bleb Structures Improve mRNA Transfection Potency

  2026-08-15

  A 2023 Advanced Materials study shows that mRNA-rich bleb structures in lipid nanoparticles can be induced by formulation conditions, including concentrated sodium citrate at acidic pH. The work shifts attention from ionizable-lipid chemistry alone toward buffer selection, mRNA integrity, and formulation-dependent determinants of transfection.

• Proteinase K for Reliable Cell Assay Workflows

  2026-08-14

  Proteinase K (SKU K1037) supports consistent post-assay sample preparation by removing protein and nuclease contaminants before DNA-based analysis. This scenario-driven guide explains compatibility, optimization, interpretation, and vendor-selection considerations for biomedical laboratories.

• CHIR-99021 (CT99021): Assay Reliability

  2026-08-14

  Learn how CHIR-99021 (CT99021), SKU A3011, can help laboratories separate pathway effects from true cytotoxicity, standardize dosing, and improve interpretation of stem-cell viability and differentiation assays. The guide connects practical handling recommendations with biochemical specifications and published evidence.

• Platycodin D Targets RFC4 in NSCLC Proteomics

  2026-08-13

  A 2026 Molecular & Cellular Proteomics study integrates thermal proteome profiling, cellular thermal shift analysis, peptide-centric stability mapping, and proteomics to identify RFC4 as a binding target of Platycodin D in non-small cell lung cancer. The work connects RFC4 engagement with reduced Notch1/Notch3 signaling, altered ubiquitination, and apoptosis, providing a mechanistic framework for studying natural-product responses in NSCLC.

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