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br Material and methods br Results Diagrammatic representati
2019-12-02

Material and methods Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1. Discussion The present results provide the first evidence that both CRF1 and CRF2 receptors in the BSNT are involved
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br Acknowledgments The authors thank
2019-12-02

Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction
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CPH models reported usually as
2019-12-02

CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature. One such model is the CPH model created for the purpose of predicting the probability of one year survival of patients suffering from Pulmonary Arterial Hypertension [5]. The model
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spleen tyrosine kinase This article is based on previous
2019-12-02

This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip
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Yet the standards fall back on
2019-12-02

Yet, the standards fall back on the development process with justification. As shown by Littlewood and Strigini (1993), the extent to which the reliability of software (both OTS and bespoke) can be proved by testing is severely limited––not because appropriate tests cannot be devised, but because ad
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br Materials and methods br Results
2019-12-02

Materials and methods Results Discussion Neointimal VSMC accumulation contributes considerably to vessel occlusion observed in both autologous vein graft degeneration [1], [2] and in-stent restenosis [26], [27]. In this study, the potential for retarding VSMC proliferation and hence amelior
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L-685,458 Apparently no study has been undertaken on alterat
2019-12-02

Apparently, no study has been undertaken on alterations in cholinesterase activity and its correlation with neurological disorders in clinical case of trypanosomosis in buffaloes. Therefore, the present study was undertaken to evaluate the alterations in cholinesterase activity in clinical cases of
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Our recent QTL mapping study revealed that the adaptor genes
2019-12-02

Our recent QTL mapping study revealed that the adaptor genes, including the NCK genes and the ABI genes, are located within the genomic regions harboring the most significant QTL (Zhou et al., 2017), suggesting that these genes could be involved in the determination of resistance, and possibly throu
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br Acknowledgment S A was
2019-12-02

Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G. Introduction Neutrophils are innate immune Furegrelate sodium salt of primary importance for protecting against infections by microorganisms [1,2] through various antimicrobial abilities, including microorganism phagocyt
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There is evidence that the response of CYP activity to
2019-12-02

There is evidence that the response of CYP450 activity to DEX is species-specific. CYP1A and CYP3A expressions were strongly induced by DEX in porcine hepatocytes (Rasmussen et al., 2014) and in rat and human, but not minipig or beagle dog hepatocytes (Lu and Li, 2001). Within fish, there are also s
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Flavopiridol hydrochloride We report here that DAPK signalin
2019-11-30

We report here that DAPK signaling pathways play significant roles in OGD-induced neuronal death. Exposure of the Flavopiridol hydrochloride to OGD led to DAPK activation, which then promoted cell death through BimEL overexpression. Furthermore, DAPK-induced BimEL overexpression was mediated by inac
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Since free testosterone diffuses into a target organ a
2019-11-30

Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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Damage of PE HD due to both mechanisms is
2019-11-30

Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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Although it was shown that IL signaling
2019-11-30

Although it was shown that IL-23 signaling induces expression of T17 pathogenic signature genes through activation of STAT3,, transcription factors other than STAT3 are also implicated for induction of pathogenic T17 cells because IL-6, which activates STAT3 similarly to IL-23, cannot induce IL-23R
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dabigatran etexilate Synthesis of and is described in
2019-11-30

Synthesis of 5–7, 12–14, and 18 is described in Scheme 3. Compounds 5–7 and 18 were prepared as outlined in Scheme 3a. Reaction of 4-bromomethylbenzoic dabigatran etexilate (36) with thionyl chloride yielded the corresponding acid chloride, which was converted to the corresponding amide 40a by the
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