• br Introduction Acinetobacter baumannii is a

  2021-06-04

  

  Introduction Acinetobacter baumannii is a gram-negative opportunistic pathogen that causes nosocomial infections including pneumonia and bloodstream infections which is associated with an increased mortality and multi-drug resistance [[1], [2], [3]]. A. baumannii was rated as one of the critical

• Introduction Mycobacterium leprae the causative agent of

  2021-06-04

  

  Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1]. Although leprosy has been eradicated from most of the countries, it still affects approximately a quarter of a million people from India [2]. Details of many bacteriol

• br The contribution of Interference RNA and

  2021-06-04

  

  The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions

• Furthermore collagen could be further utilized

  2021-06-03

  

  Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as polymer materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the proper

• In S cerevisiae Mek a paralog

  2021-06-03

  

  In S. cerevisiae, Mek1, a paralog of the checkpoint kinase Chk2, mediates cell-cycle arrest in response to meiotic defects (Bailis and Roeder, 2000, Xu et al., 1997). Mek1 is associated with meiotic chromosome axes, where its activation requires interactions with two other axis proteins, Hop1 and Re

• With regards to translational development of

  2021-06-03

  

  With regards to translational development of SMEPT, we acknowledge that we are not aware of any trials currently underway to validate this methodology in clinical settings. It appears fair to say that enthusiasm and commitment from corporate developers does not match that of academic partners. One r

• br Introduction Cerebral stroke causes an

  2021-06-03

  

  Introduction Cerebral stroke causes an efflux of various groups of progenitor and stem cells from bone marrow to bloodstream and the levels of these cells correlate with neurological status of stroke patients (Gójska-Grymajło et al., 2012, 2018). It is thought that paracrine factors produced by t

• Enolase is an example of a moonlighting protein that display

  2021-06-03

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• br Conflict of interest br Introduction

  2021-06-03

  

  Conflict of interest Introduction Endothelin receptors are members of the superfamily of G-protein-coupled receptors (GPCRs) and central regulators of vascular tension and other physiological functions in higher eukaryotes [1]. The human endothelin system comprises the highly homologous endoth

• It has been reported about the synthesis of

  2021-06-03

  

  It has been reported about the synthesis of benzyl bromide in our previous reports, as shown in , , The synthetic route of compounds – is depicted in , Briefly, the synthesis of pyrimidinedione derivatives was started from commercially available BAMB-4 australia . After alkylation of material with 1

• Introduction Amphetamine AMPH methamphetamine MA and ethylen

  2021-06-03

  

  Introduction Amphetamine (AMPH), methamphetamine (MA), and 3,4-ethylenedioxymethamphetamine (MDMA) are widely abused psychoactive substances, with the basic chemical structure of phenylethylamine [1]. The abuse of these drugs is associated with psychostimulant, anorectic and hallucinogenic propert

• We then undertook computational studies that suggest

  2021-06-02

  

  We then undertook computational studies that suggest the cyanobacterial ALDH (and planctomyces ALDH) represent the evolutionary ancestor of human and other eukaryotic ALDH1/2 given that cfALDH contains signature residues matching both the human proteins throughout the surface of the protein and the

• To assess which export pathway is used by

  2021-06-02

  

  To assess which export pathway is used by the iNOS mRNA, we inhibited CRM1 activity by incubation of DLD-1 retinoic acid receptor with LMB. Since LMB covalently and exclusively binds to CRM1, it represents a potent and specific inhibitor of the CRM1 transport activity [38]. Inhibition of CRM1 activ

• br Materials and methods br Results br Discussion

  2021-06-02

  

  Materials and methods Results Discussion In this study, we investigated two novel candidate therapeutics, the related CRM1-inhibiting SINEs KPT-185 and KPT-276, in treatment of NHL. The results showed that KPT-185 induced growth inhibition, cell-cycle arrest, and apoptosis in tumor protease

• br Acknowledgements We thank Jeus Perez Clausell

  2021-06-02

  

  Acknowledgements We thank Jeus Perez-Clausell from the Department of Cell Biology, School of Biology, University of Barcelona, Felipe Casanueva's group from the Department of Molecular Endocrinology and Carlos Diéguez's group from the Department of Physiology, School of Medicine, University of Sa

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