• br Acknowledgements Authors wish to thank Sabanci University

  2024-03-15

  

  Acknowledgements Authors wish to thank Sabanci University (Turkey), Tubitak (Cost Eu-Ros, 113Z463), and the University of Turin (Italy) for supporting this work. Beyza Vurusaner is supported by Sabanci University Post-doctoral research scholarship. Introduction Endometriosis is defined as the

• br Autophagy in cancer br Phytochemicals as a valuable sourc

  2024-03-15

  

  Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cance

• br Acknowledgement This work was funded by NIH

  2024-03-15

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

• Aurora B is also known

  2024-03-15

  

  Aurora-B is also known as chromosomal passenger protein and localizes at the chromosome arms and at centromeres during prophase. As cell cycle continues, Aurora-B moves towards the inner centromere region followed by the central spindle and cortex during TOK-001 and finally accumulates in the midbod

• br Colorectal carcinoma The growth rate of murine colon

  2024-03-15

  

  Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c

• br Author contributions br Acknowledgments TJC KW and

  2024-03-15

  

  Author contributions Acknowledgments TJC, KW, and VG are supported by awards made to MJN: a Consolidator Grant from the European Research Council under Grant no. 311336; a University Research Fellowship from the Royal Society, and a Career Development Award from the Human Frontiers Science Pro

• Several structural classes of ASK inhibitors

  2024-03-15

  

  Several structural CM-272 receptor of ASK1 inhibitors, mostly from industry but also from academia, have been identified over the last decade. In 2012, Terao et al. (Takeda) reported imidazo[1,2-α]pyridine () as a potent ASK1 inhibitor derived from structure-based drug design. GSK, Merck and Gilea

• To further evaluate the influence of antibiotics on allergy

  2024-03-14

  

  To further evaluate the influence of gsk3 inhibitor on allergy, Russel et al. initiated vancomycin treatment during pregnancy in mice and continued it for several weeks after birth. This resulted in exaggerated OVA-induced allergic inflammation, characterized by higher numbers of lung eosinophils,

• Tetracyclines constitute one of the most important antibioti

  2024-03-14

  

  Tetracyclines constitute one of the most important antibiotic groups used as veterinary and human medicine and as feed additives in the agricultural sector (Li et al., 2011a, Simon, 2005). Annual worldwide production of tetracyclines is estimated to be in the thousands of tons (Michalova et al., 200

• Introduction Cardiovascular disease is the principal

  2024-03-14

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with tcid (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular risk fa

• The chronic induction of skeletal muscle AMPK activity

  2024-03-14

  

  The chronic induction of skeletal muscle AMPK activity is an attractive therapeutic approach for DMD, as it addresses multiple cellular pathways needed for powerful phenotypic plasticity, including activation of the slow oxidative myofiber program, corrective autophagic signaling, as well as regulat

• The SMN and SMN promoters are regulated by

  2024-03-14

  

  The SMN1 and SMN2 promoters are regulated by transcription factors such as E26 transformation-specific domain containing protein (ELK-1) and cAMP response element-binding protein (CREB) 58, 59. Compared with WT animals, mice with SMA exhibit increased and decreased ELK-1 and CREB phosphorylation, re

• Gemcitabine Polycyclic aromatic hydrocarbons PAHs are abunda

  2024-03-14

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, Gemcitabine burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs have be

• The results also showed that the A receptor http www

  2024-03-14

  

  The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 HO-3867 synthesis stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection m

• Control of retinal vascularization during development and OI

  2024-03-14

  

  Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial atm kinase inhibitor (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a critical rol

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