• Using our screening we were able to confirm the previously

  2018-11-06

  

  Using our screening, we were able to confirm the previously determined cytogenetic karyotypes of 34 mESC lines and to further validate our method using 19 additional mESC lines with unknown cytogenetic karyotypes. Our study includes the screening of five mESC lines that produced germline transmissio

• br Results br Discussion We have demonstrated that

  2018-11-06

  

  Results Discussion We have demonstrated that the hPSC-derived HBCs could be maintained on a human LN111-coated dish in an integrin α6- and β1-dependent manner (Figure 1). It is known that undifferentiated hPSCs could be maintained on a human LN511-coated dish but not on a human LN111-coated di

• br Conclusions The following are

  2018-11-06

  

  Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for

• The reversion of somatic cells

  2018-11-06

  

  The reversion of somatic Phos-tag Acrylamide to pluripotent cells is referred to as reprogramming. Recently, much of the focus of studies has been on the issue of how to overcome the low reprogramming efficiency (Esteban et al., 2010). Here, we uncovered a new role of JNK-mediated Klf4 phosphorylat

• br Materials and methods br

  2018-11-06

  

  Materials and methods Results Discussion Here we show that continued (albeit prolonged) culture of plastic hFibOCT4 in RM media is sufficient for induction of pluripotency. Importantly, iPSCOCT4 possess morphological, biomolecular, and functional hallmarks of bona fide PSCs (K.R. Salci et a

• Micro array data has been

  2018-11-06

  

  Micro-array data has been submitted to Gene Expression Omnibus with GEO accession number: GSE72118. Competing financial interests Acknowledgements Introduction Recent studies in the stem cell field have demonstrated that cell fate transition could be achieved by introducing lineage-specifi

• br Resource table Resource details Expanded T cells isolated

  2018-11-06

  

  Resource table: Resource details Expanded T E 64 isolated from a 38year-old Japanese healthy male were reprogrammed employing Sendai virus vectors (SeVdp) expressing four reprogramming factors, OCT3/4, SOX2, cMYC, KLF4. SeVdp is integration-free vector, and the absence of reprogramming genes in

• The numbers of GFAP NSCs did not

  2018-11-06

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

• ARQ197 In addition recent findings indicate that the

  2018-11-05

  

  In addition, recent findings indicate that the majority of in vitro expanded cells undergo apoptosis upon implantation (Stegen et al., 2016). A cause may be the need to instantly adjust to a compromised environment, since current culture conditions represent a rather non-physiological and abundant n

• Accumulating evidence indicates that treatment using extrace

  2018-11-05

  

  Accumulating evidence indicates that treatment using extracellular vesicles (EVs) have multiple advantages over cell therapy, because EVs are stable in the circulation without losing function and exhibit a superior safety profile (Vader et al., 2016). In particular, MSCs are an attractive source of

• br Understanding patterns of informal care

  2018-11-05

  

  Understanding patterns of informal care provision between 2001 and 2011 In order to understand patterns of informal care provision between 2001 and 2011, a typology of caring transitions was used to capture change (or the lack of it) in the provision of informal care between 2001 and 2011 and the

• Cross border ties have been conceptualized primarily from th

  2018-11-05

  

  Cross-border ties have been conceptualized primarily from the sociological literature in the context of international migration, with the concept of “border” pertaining to a nation-state boundary (Waldinger, 2015, 2013); however, there have been recent calls to better understand how international mi

• Harman and Stewardson mentioned that only

  2018-11-05

  

  Harman and Stewardson (2005) mentioned that only a few published studies explicitly described the link between environmental flow targets and dam operating rules. To resolve the river management-driven issues and bridge the gap between a simple minimum stream flow target and the great complexity of

• br Late Cretaceous magmatism mineralization geochronological

  2018-11-05

  

  Late Cretaceous magmatism–mineralization geochronological frameworks in southeast Yunnan and northeast Vietnam The tin polymetallic mineralization and related igneous rocks in the western South China Block have attracted some interests in past decades (Tu et al., 1984; Xie et al., 1984; 308 Geolo

• Circulating cell free DNA cfDNA has

  2018-11-05

  

  Circulating cell free DNA (cfDNA) has been investigated in patients with solid tumors and circulating tumor DNA (ctDNA) is reported to be detectable in a wide range of malignancies (Bettegowda et al., 2014). In solid tumors there is evidence that ctDNA is an effective biomarker at predicting relapse

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