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Human iPSC lines are usually produced from fibroblasts isola
2018-10-22
Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and a non-invasive alternative procedure. In the genuine study demonstrating
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To determine if subepithelial cells such as
2018-10-22
To determine if subepithelial cells, such as SEMFs, are a required physiologic Wnt source, we used Myh11-Cre mice. Myh11-encoded smooth-muscle myosin heavy chain is expressed in much of the intestinal subepithelium (Wirth et al., 2008). To define the precise expression domain, we crossed Myh11-Cre t
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Introduction Self renewal and the potential
2018-10-22
Introduction Self-renewal and the potential to differentiate into any cell type are the defining features of pluripotent stem cells (PSCs). Maintaining the kinesin inhibitor in this unique state is a carefully regulated process that requires the coordinated interaction of multiple transcription fa
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In the subsequent sections we
2018-10-20
In the subsequent sections we attempt to consolidate and discuss recent findings that have emerged from the study of the reprogramming process. Primarily, this is composed of three phases: initiation, maturation and stabilization and are discussed in greater detail below (Fig. 2). Second mileston
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br Materials and methods br Data analysis
2018-10-20
Materials and methods Data analysis All results are presented as means±SEM. Comparisons between groups were analyzed using t-tests (two-sided). Differences with p values of less than 0.05 were considered significant. The p values were corrected for multiple testing procedures and to control ty
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At this point it is worthwhile mentioning that the
2018-10-20
At this point it is worthwhile mentioning, that the B27 supplement can be purchased containing 0.3μM retinyl acetate which is a biologically inactive storage form of vitamin A. However, only dietary retinol bound to the retinol binding protein 4 (RBP4) is taken up into caspofungin where it can then
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br Defining electromagnetic field parameters When discussing
2018-10-20
Defining electromagnetic field parameters When discussing cellular influences by either endogenous or exogenous fields, it is important to define the nomenclature. In this discussion, the term electromagnetic field is used to summarize the whole field, which includes “electric,” “magnetic” and co
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cellular metabolism br Methods br Results br Discussion
2018-10-20
Methods Results Discussion Our method for osteoprogenitor cell culture is similar to protocols for mice (Meirelles and Nardi, 2003; Soleimani and Nadri, 2009; Nardi and Camassola, 2011; Abdelmagid et al., 2014; Fig. 1). Marrow and cortex-derived cell populations of bats and mice shared sim
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br Materials and methods br Results br Discussion
2018-10-20
Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e
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br Introduction Stem cells play a crucial role in maintainin
2018-10-20
Introduction Stem neuronal nitric oxide synthase play a crucial role in maintaining tissue homeostasis. In this context, interplay between stem cells and their microenvironment, also known as the niche, is necessary for the maintenance of stem cell phenotypic state (Scadden, 2014). In general, d
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In this study we show the feasibility of infecting
2018-10-20
In this study, we show the feasibility of infecting iHLCs with Plasmodium sporozoites in vitro and demonstrate Plasmodium parasite development over time in culture. We identify the stage at which adenosine receptor agonist acquire permissiveness to liver-stage malaria infection during the different
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br Experimental Procedures br Author Contributions
2018-10-20
Experimental Procedures Author Contributions Acknowledgments The authors thank Sarah Chan and Jonathan Scolnick for technical assistance with deep sequencing and Yusuf Ali, Hiram Chipperfield, Rory Johnson, and Pauline Tay for their early work on the pancreatic differentiation protocol and
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syk inhibitors br Experimental Procedures br Author Contribu
2018-10-20
Experimental Procedures Author Contributions Acknowledgments Introduction With the first reports on generating human induced pluripotent stem syk inhibitors (hiPSCs) from human cells (Takahashi et al., 2007; Yu et al., 2007), the controversy regarding the ethics of research involving hu
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Previously in vitro studies of CIPN were
2018-10-20
Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al., 2
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To explore the potential mechanism underlying this interesti
2018-10-20
To explore the potential mechanism underlying this interesting phenomenon, we examined the role of mTOR in this process as mTOR is well known for its role in controlling cell growth and metabolism, and more importantly, it is known to crosstalk with GSK3 (Inoki et al., 2006). Indeed, we were able re
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